Baclofen for Hiccups: How This Muscle Relaxer Stops Persistent Hiccups

When hiccups last longer than 48 hours, they’re not just annoying—they can wreck sleep, eating, and even mental health. That’s where baclofen, a muscle relaxant originally designed for spinal cord injuries and multiple sclerosis. Also known as Gablofen, it works by calming overactive nerve signals in the brainstem that trigger the diaphragm spasms causing hiccups. While not approved by the FDA for hiccups, it’s one of the most studied off-label treatments for chronic cases, especially when other options fail.

Chronic hiccups often tie into neurological issues, like brain tumors, strokes, or nerve damage from surgery. Baclofen targets the GABA-B receptors in the central nervous system, reducing the erratic firing that keeps the diaphragm contracting. Studies show relief in up to 80% of patients with intractable hiccups, sometimes within hours. It’s not a quick fix for a one-day case, but for those stuck in a loop of hiccups for weeks or months, it can be life-changing. Side effects like drowsiness, dizziness, or weakness are common but usually mild and fade as the body adjusts.

Other muscle relaxers like gabapentin or benzodiazepines are sometimes tried, but baclofen stands out because it works directly on the root cause—not just masking symptoms. It’s often used when antacids, anti-nausea meds, or even acupuncture don’t cut it. If you’ve tried everything and your hiccups won’t quit, this might be the next step your doctor hasn’t mentioned yet. Below, you’ll find real patient experiences, dosing insights, and what to watch for when using baclofen for something it wasn’t originally made for.